An Analogue of Joro Spider Toxin Selectively Suppresses Limbic Seizure Induced by Quisqualate Receptor Agonists.
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1-Naphthylacetyl spermine (1-NA-Spm), an analogue of a Joro spider toxin (JSTX), is known as a specific blocker of glutamate receptors. The anticonvulsant effect of 1-NA-Spm against the seizures induced by specific agonists of glutamate receptor subtypes was investigated electrophysiologically and behaviorally in freely moving rats. Electrodes were implanted into the right dorsal hippocampus and an injection cannula for drugs into the right ventricle. The pretreatment with 1-NA-Spm (20μg) significantly reduced hippocampal epileptic discharges induced by both quisqualate receptor agonists, quisqualate (30μg; 80 to 11%) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA; 1μg; 55 to 9%). 1-NA-Spm had no effect on the seizures induced by quinolinic acid (30μg), an NMDA receptor agonist, and by domoic acid (0.8μg), a kainate receptor agonist. The present study provides the direct evidence that the 1-NA-Spm shows a potent and selective suppression of the seizures mediated by quisqualate (AMPA) receptors.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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