視覚刺激で誘発される棘徐波に対するバルプロ酸の抑制作用に関する研究

概要

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The effect of single oral dose of valproate (VPA) on the paroxysmal responses in EEG to various colored striped pattern reversal stimulation was tested in eight patients with photosensitive epilepsy. The photosensitivity ratio (PSR) was studied before and after VPA administration. PSR indicates the ratio of pattern reversal frequencies to which the patient is sensitive in a limitted frequency range. The change in PSR was evaluated as a percent ratio (%PSR) by comparing it with the time-matched PSR before administration.<BR>In most cases, %PSR decreased rapidly in inverse proportion to the increase in serum VPA level. Even during subsequent decrease in serum VPA concentration, %PSR remained low for more than several hours with an initial rebound. In these patients, %PSR had been kept under 50% for much longer than therapeutic serum level (>50μg/m<I>l</I>) being maintained.<BR>The trend between PSR and serum VPA level suggests that PSR would serve as a useful indicator of photosensitivity.
一般社団法人日本てんかん学会の論文