Multi-institutional Study on Possibility of Prediction of Long-term Prognosis in Temporal Lobe Epilepsy.

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A multi-institutional study on long-tem prognosis of temporal lobe epilepsy was performed, to investigate possibility of prediction of outcome of seizure in the early stage therapy. The subjects were 76 cases with temporal lobe epilepsy who were examined between January 1971 and December 1980 and had been observed until December 1990 without interruption.<BR>Statistically significant correlations were found between seizure condition in the second year of therapy and long-term prognosis and also between the presence of neuropsychiatric complications in the second year and the prognosis.<BR>Namely, among 21 cases who had no seizure in the second year of therapy, 86%were in remission (seizure-free for 3 years or more) at the study, while only 29% of patients who had seizures in the period were in remission. In all of 11 cases with not only frequent seizures but also neuropsychiatric complications in the second year of therapy, their seizures have not been controlled at the time of study.<BR>Accordingly, the authors concluded that the patients with frequent seizures and neuropsychiatric complications in the second year of therapy will have an unfavorable long-term prognosis.
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