A Study on Neurophysiological Mechanism of the Gelastic Seizure. Estimations of Electrical Source generators by Means of the Dipole Tracing.:Estimations of Electrical Source generators by Means of the Dipole Tracing
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In this study the Dipole Tracing method (DT; Nakajima et al. 1990) was applied to clarify the pathophysiological process of the gelastic seizure. The subject was a fifteen-year-old girl suffering from only gelastic seizures since age nine. The main ictal symptom was a laughter with mirth, and her interictal EEG showed right anterotemporal spike and waves in earlier periods. The ictal EEG at this time revealed fast desynchronization followed by rhythmic slow wave bursts. In the course of two years, the spike and waves had changed into multiple spike and waves. Corresponding to this EEG change, DT was applied to assess the source generators of the spikes; single spike and waves in the earlier and multiple spike and waves in the later period.<BR>The equivalent current dipoles (ECDs) corresponding to the single spike were located in the right mesial temporal region (presumably amygdalo-hippocampal area). As to the multiple spikes, the ECDs of the first spikes were localized to the same region as of the single spike and those of the second were in the medial frontal lobe (presumably cingulate region). <SUP>123</SUP>I-IMP SPECT examination confirmed the presence of hyperperfusional areas in both the medial frontal and right temporal lobes.<BR>These results present supporting evidence for the notion that the propagation of the epileptic discharges from the amygdalo-hippocampal region to the adjacent limbic areas, especially to the cingulate, plays an important role in the pathogenesis of gelastic seizures.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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