Persistent Changes of Specific (3H)GTP Binding Ability in the Cerebral Cortex of Amygdaloid Kindled Rats.
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We perfomed the specific [<SUP>3</SUP>H] GTP binding assay to the cerebral cortical membrane in the amygdaloid kindled rats to elucidate the biochemical bases of epileptogenesis.<BR>Crude membrane fractions of bilateral cerebral cortex obtained from kindled and sham-operated control rats were incubated with [<SUP>3</SUP>H] GTP in the presence or absence of isoproterenol (IPN), a β-agonist. The data were analyzed by Scatchard analysis.<BR>There were no differences in B<SUB>max</SUB>and K<SUB>d</SUB>values in basal (without IPN) binding, between kindled and control groups. In the presence of IPN, B<SUB>max</SUB>values increased in the control, but did not increase in the stimulated (left) and unstimulated (right) side of the kindled group. The attenuation of IPN effect on B<SUB>max</SUB>in GTP binding assay was observed at 24h after the last generalized seizure and persisted for two weeks.<BR>These results suggest that decrease in the ability of Gs to bind GTP may be concerned with the generation of the epileptic seizure and the aquisition mechanisms of the long-lasting epileptogenesis in the kindling model of epilepsy.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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