Auditory Brainstem Response and Fos Immunoreactivity in Central Auditory Pathway in an Acquired Audiogenic Seizure Model in Rats.

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An acquired audiogenic seizure model was created in rats by exposing them to intense 1/3 octave band noise (4 kHz, 125 dB) delivered two times, on post-natal days (P) 14 and 28. On P 28, "wild-running" (WR) was induced by sound in rats which had been formerly exposed to the sound stimulus on P 14. In stimulated rats and/or those with seizures, changes in auditory brainstem response (ABR) were characterized by a rise in the sound level threshold, indicative of cochlear hearing impairment, a decrease in the amplitude ratio of waves II and III to wave I, and prolongation of the interpeak latency between waves I and IV.<BR>In the rats with seizures, many cells showing Fos-like immuno-reactivity were found in the lateral lemniscus, inferior colliculus, medial geniculate body, and temporal cortex, and the nerve cells in these nuclei showed slight histopathological change.<BR>The central part of the inferior colliculus which is critical for initiation of audiogenic seizure is not expressed in non wild running rats, suggesting that activation of this area by a single audiogenic seizure is not sufficient to induce long-lasting changes. Strong acoustic stimuli induce an abnormal response in the inferior colliculus, accompanied by a wild running phase. These results confirm that audiogenic seizures are brain-stem seizures relatred to dysfunction of auditory pathways.
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