Unexpected death upon recovery from status epilepticus induced by intracerebral folic acid injection in cats.
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We report "unexpected death" following what appears to have been complete recovery from status epilepticus induced by intracerebral microinjection of folic acid (FA) into either amygdala or substantia innominata through chronic canula. These experiments were originally designed to study the effect of status epilepticus upon subsequent amygdaloid kindling. With FA injection all the animals developed "limbic" seizure leading to convulsive status epilepticus reaching its peak at about 3 hrs but dissipating over 1-4 days. One cat died in prolonged convulsive status epilepticus, while five cats recovered. completely only to become acutely ill in 2-4 weeks and died rather suddenly. Histopathological findings of the brain showed inconsistently lateralized edema and shrinkage and pyknosis of nerve cells localizing in the hippocampus and front-temporal corticies. The most impressive pathological finding was myocardiac damage caracterized by an extensive "wavy fibre pattern" of both the left and right ventricle with numerous "transverse contraction bands". Cause of deth was considered as acute myocardial ischemia related with increase of catecholamine release at the sympathetic nerve terminals of the heart.<BR>While intracerebral microinjection of FA into amygdala of cats under nembutal anesthesia produced electrographic discharge readily propagating mainly into the ipsilataral hemisphere with minimal clinical manifestations leaving no evidence of lasting change in behavior and seizure susceptibility as examined by kindling at the same site.<BR>We concluded as follows:<BR>1) Status epilepticus can have not only immediate but also remote and serious consequences.<BR>2) Rapid and effective control of status epilepticus is vital for prevention of delayed and untoward consequences.<BR>3) Intracerebral folic acid injection may be a useful tool to study the poorly understood phenomenon "SUD in epileptics".
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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