Status epilepticus induced by intracerebral folic acid injection in cats. Clinical, electroencephalographic, pathological study.:Clinical, Electroencephalographic, Pathological Study
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Recently, intracerebral folic acid (FA) injection was reported to produce status epilepticus (SE) associated with extensive neuronal damage considered to reflect primalily lesion of GABA-ergic neurons in rats. Since earlier studies in our laboratory suggested the possibility that substantia innominata (SI) plays an important role in amygdaloid kingdling (Am K), we planned to examine (1) the effect of SE, induced by FA injection into the Am upon subsequent seizure development at the same Am site by kindling, and (2) the possible role of GABA-ergic neurons, reported to be selectively vulnerable to FA when injected into SI, play in Am K in cats. The present study was undertaken to investigate acute effects of SE induced by microinjection of FA into Am or SI through chronic canula. EEG, EKG, and urinary samples were obtained continuously before, during, and after SE.<BR>Regardless of where FA was injected, all the animals developed SE with recurrent stage 1-6 Am K seizure manifestations reaching a peak in about 3 hrs, gradually subsiding within 5 days. Motor seizure symptom appeared relating with reactive after discharge in motor cortex and hippocampus. Generalization followed appearance of reactive afterdischarge in midbrain reticular formation as reported in Am K.<BR>There was no significant change in EKG except for a marked increase of cardiac rate during SE. Similarly transient myoglobuinuria and significant increase of urinary output of noradrenaline were observed at the time of SE. At the 14th day after FA injection all animals were sacrificed and examined histopathologically. There was a little evidence characterized by shrinkage and pyknosis of nerve cells with some macrophage proriferations localizing in the pyriform cortex and hippocampus. Other organs including the heart were normal. Thus no evidence of severe neuronal damage reported in rats was found, suggesting a significant species difference.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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