Influence of sodium valproate on 10,11-epoxidation and trans-10,11-diol formation in metabolism of carbamazepine.
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Carbamazepine (CBZ), its 10, 11-epoxide (CBZE) and trans-10, 11-dihydrodihydroxy-CBZ (CBZ-diol) in serum were measured simultaneously by high pressure liquid chromatography in 48 patients treated with CBZ and in 19 received combined treatment of CBZ and sodium valproate (VPA).<BR>Obtained results are as follows.<BR>1) In patients with monotherapy, the raito of CBZE/CBZ showed linear correlation to the dose of CBZ (mg/kg).<BR>2) In patients with combined therapy of VPA, there was a significant correlation between the ratio of CBZE/CBZ and serum levels of VPA. And, the ratio of CBZE/ CBZ was higher in patients with combined therapy of VPA than with monotherapy.<BR>3) The ratio of CBZ-diol/CBZ was higher in a group of combined therapy of VPA than with monotherapy, but the ratio of CBZ-diol/CBZE showed no difference between two groups.<BR>These results suggested that VPA accelerated the epoxidation and had no influence on trans-diol formation in the metabolism of CBZ.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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