A longitudinal follow-up study for over 10 years of children with grand mal.
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概要
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510 children with grand mal (first diagnosed at the age less than 15 years), who were followed up for over 10 years were studied.<BR>By their prognosis, the subjects were divided into three groups: group A (favorable outcome): 276 cases (54%), who were off-medcation without relapse for at least one year.<BR>group B (moderate outcome): 159 cases (31%), who had been seizure-free for more than 5 years but dependent on medication or reducing the dosage of medication.<BR>group C (poor outcome): 75 cases (15%), who were seizure-free for less than 5 years.<BR>The remission rate was 85% for the five-years period. The relapse rate was 9% after withdrawal of drugs.<BR>Factors for favorable outcome (group A) were as follows:<BR>1) The onset of seizure at less than 6 years of age.<BR>2) Duration of seizures less than 5 years.<BR>3) Seizure control by the age of 10 years.<BR>4) Normal mentality.<BR>5) Seizure attack only with fever.<BR>6) Disappearance of seizure discharge (focal or multi focal spike, diffuse spike and wave, their complications, etc.) in EEG by the age of 15 years.<BR>On the contrary, factors of poor outcome (group C) were as follows:<BR>1) The onset of seizures at more than 10 years of age.<BR>2) Duration of seizure more than 10 years.<BR>3) Mental retardation.<BR>4) Afebrile seizure.<BR>5) Later disappearance of seizure discharge in EEG.<BR>In the relapse cases, there was a tendency to earlier reduction of medication in spite of no disappearance of seizure discharge in EEG, which were compared with complete remssion cases.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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