A clinical study on the effectiveness of intermittent therapy with rectal diazepam suppositories for the prevention of recurrent febrile convulsions. A further study.
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The clinical efficacy of intermittent therapy with rectal diazepam (DZP) suppositories for the prevention of recurrent febrile convulsions was studied. The dosage schedule used for rectal DZP suppositories was based on the results of the pharmacokinetic analysis reported previously.<BR>One hundred and thirty-three children aged 10 months to 4 years with two or more previous febrile convulsions were treated intermittently with rectal DZP suppositories. Suppositories containing 0.5mg/kg of DZP were given rectally to the patients at home as soon as the initial signs of febrile illness were noticed by their parents. A DZP suppository of the same dose was administered again 8 hours after the first dose, when the fever still remained above 38.0°C. The patients were followed closely for 6 to 43 months at our pediatric seizure clinic.<BR>Of the total of 787 febrile episodes above 38.0°C in all patients during the followup period, DZP suppositories were administered to the patients in 722 cases (91.7%), including 47 cases in which DZP suppositories were administered soon after the occurrence of seizures. Thirty-eight of the 133 patients (28.6%) had a total of 58 recurrences of febrile convulsions (7.4% of the total of 787 febrile episodes), of which two recurrences were observed at 7 and 9 hours after administration of the first DZP suppositories, respectively. In 39 cases of the remaining 56 recurrences, the patients were noticed to have fever first after the occurrence of seizures. However, in the cases of the other 17 recurrences, DZP suppositories were not administered to the patients arbitrarily, even if the fever was noticed by the parents before the occurrence of seizures.<BR>No serious side effects except for mild drowsiness and transient ataxia were observed in any of the patients.<BR>Intermittent therapy with rectal DZP suppositories at home seems to be safe and remarkably effective for the prevention of recurrent febrile convulsions, unless the timing of administration is delayed in cases of febrile episodes.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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