A comparative study of hippocampal kindling and amygdaloid kindling in suckling rats.
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Development of hippocampal kindling was compared with that of the amygdaloid kindling in suckling rats. In amygdaloid kindling rats (n=12), an hourly electrical stimulus (400μA, 1 ms, biphasic square pulses, 62.5 Hz for 2 sec), twenty times a day, was applied to the left amygdala at 16 days of age. In hippocampus, the other 20 rats received the fourty kindling stimuli (fifteen times a day at 16 and 17 days of age and ten times a day at 18 days of age) to the left dorsal (n=8) or the ventral (n=12) hippocampus. If afterdischarge (AD) was not evoked by an 400μA current, stimulus intensity was increased to 800μA. If it was still ineffective, the animals were discarded from the data. The results were as follows.<BR>1) In the hippocampal kindling, sixteen of 20 rats (80%) developed a generalized convulsion with the mean number of 23.3 stimulations. However, the other rats (20%) remained a focal seizure within the 40 stimulations. In the amygdaloid kindling, all rats (n=20) developed a generalized convulsion within 20 stimulations (the mean number; 13.2).<BR>2) The mean duration of AD changed from 43. 3 sec for the initial AD to 84.7 sec for the first generalized convulsion (two fold increase) in the hippocampal kindling. On the other hand, the change of AD duration was 4.3 fold (12.4 sec to 53. 6 sec) in the amygdaloid kindling.<BR>3) A marked difference was observed in the behavioral seizures of wet dog shakes (WDS) between the hippocampal and the amygdaloid kindlings.<BR>4) There was no apparent difference in the pattern of kindling progression between the dorsal hippocampal and the ventral hippocampal kindlings.<BR>A discussion was made on the hippocampal and the amygdaloid kindlings to understand the basic mechanisms underlying the critical susceptibility of immature brain to seizures.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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