Neural mechanism of epileptic automatism in amygdaloid kindling.
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Several features of amygdaloid kingling support that it is an animal model of complex partial seizures; first the behavioral pattern of kindled seizure resemble to those of the human complex partial seizure, and secondarily EEG abnormalities are similar to those recorded from electrodes in the amygdala and the hippocampus during the seizures. The aim of this paper is to study the neural mechanism of the epileptic automatism in kindled cats, by analizing correlation of behavioral automatism and EEG afterdischarges in the amygdala and other cerebral structures.<BR>Daily electrical stimulation of the basolateral amygdaloid nucleus induced the development of seizures, generally evolving through the following stages: 1) unilateral facial twitching, 2) repetitive masticatory movement, 3) head-turning and circling to the contralateral side of stimulation, and, 4) generalized clonic or tonic-clonic convulsion. There was approximate correlation between development of behavioral automatism, and EEG afterdischarges of amygdala and of other cerebral structures. At the stage of the repetitive masticatory movement, the high amplitude rhythmic burst discharges of about 6 Hz appeared in the amygdala, which propagated to the basal forebrain (nucleus accumbens). At the next stage of the contraversive head-turning and circling, high voltage repetitive spike discharges developed prominently in the neostriatum, whereas amygdaloid discharges rather decreased in amplitude. During the progression from the head-turning to the generalized convulsion stage, there was a still more remarkable increase of afterdischarges in amplitude in all the structures, particularly in the neostriatum and the cerebral cortex.<BR>These results suggest that the basal forebrain and the neostriatum are involved in producing the perioral automatism and the head-body turning, respectively, which are observed in the human complex partial seizures, and that the neostriatum might play an important role for producing the secondary generalized convulsion, too.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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