Efficacy of Zonisamide for intractable epilepsy in childhood.
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Zonisamide (3-sulfamoylmethyl-1, 2-benzisoxazole, AD 810, CI-912) is a new anticonvulsant compound, of which properties were demonstrated in several animal models and some adults with medically refractory partial seizures. We studied its effects 39 children with intractable epilepsy. They were between 2 and 18 years of age (mean 10.0 years old) and in most of them (87.8%) their seizures repeated weekly or daily in spite of the maximal therapeutic plasma level of two or three standard antiepileptic drugs. In regard to the seizure type, 28 cases had partial epilepsy (TLE; temporal lobe epilepsy in 9 and NTLE; non-temporal lobe eilepsy in 19) and 11 cases were in secndary generalized epilepsy (LGS; Lennox-Gastaut syndrome in 9 and SGE without LGS in 2). Zonisamide was administered 2-10 mg/kg/day in addition to the previous drug for one to ten months.<BR>Ninetten of 39 cases (48.7%), 15 with partial epilepsy and 4 with generalized epilepsy showed an improvement. Nine of them (45%) improved only transiently, suggesting the development of tolerance to the drug. The average serum concentration of patients in whom the agent was effective was 16.5μg/m<I>l</I>, while those who did not respond had an average concentration was 16.7μg/m<I>l</I>. The lower limit of effective concentration was thought to be lower than in adults. Adverse effects such as drowsiness, ataxia, anorexia and liver dysfunction were common to antiepileptic drugs. On the contrary, such side effects as decreased volition and memory seemed to be related to Zonisamide. All side effects were transient or reversible and not severe.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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