A trial of once-daily administration of KW6066N for patients with functional partial and primary generalized epilepsy.
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KW 6066 N is a sustained release preparation of valproic acid (VPA) intended to prolong the rate of bioavailability by delaying the absorption velocity. Theoretically, the use of this preparation permits the patients to reduce the number of times of drug intake a day because the daily fluctuation of serum level in steady state becomes small.<BR>The authors could confirm good results by using this drug once a day after supper in 20 patients (10 cases with functional partial epilepsy and 10 with primary generalized epilepsy of which mean ages are 10 and 15 years, respectively). Their seizures had been entirely suppressed for more than six months by VPA therapy (VPA alone in 18 and in combination with carbamazepine in 2). After obtaining informed written consent of these patients or their families, VPA given hitherto was replaced by the same dose of KW 6066 N. The drugs were taken once a day after supper with the combined drugs, if any, and the clinical courses for more than 12 months were observed.<BR>Eighteen patients (90%) showed complete suppression of seizures until the end of observation periods. After shifting to KW 6066 N, there were neither patients who developed new side-effects nor cases that required the discontinuation of once daily administration.<BR>Mean level dose ratio (μg/m<I>l</I>/mg/kg) of KW 6066 N monitored early morning before drug intake was significantly higher than that of VPA (4.0±1.4 in KW6066N and 2.5±0.9 in VPA, respectively). Accordingly, slow releasing effect of KW6066N was confirmed.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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