Increased activity of superoxide dismutase(SOD) in kindled brain and suppression of kindled seizure following intracerebral injection of SOD.
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The possible role played by superoxide dismutase (SOD), a specific scavenger for superoxide, in the generalization and expression of kindled amygdaloid seizure was examined in rats.Significant increase of SOD activity was observed in the whole brain 30 days after full electrical kindling. When 3ng of SOD was injected into the kindled amygdala, marked suppression of kindled seizure was obtained.These results suggest that SOD participates in the persistence of amygdaloid kindled seizure susceptibility and the initiation of kindled amygdaloid seizure.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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