The Clinical Evaluation of Clorazepate for Refractory Childhood Epilepsies.

概要

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The antiepileptic effect of clorazepate dipotassium (CLP) was studied in 38 children with refractory epilepsy. CLP failed to produce any antiepileptic effects on 19 children with symptomatic generalized epilepsy except for 2 patients who showed a transient decrease in myoclonic seizures or atypical absences. Out of 13 patients with symptomatic partial epilepsy (SPE), long-term (more than 6 months) complete seizure control was obtained in 3 patients, and long-term excellent response (seizure frequency decreased by more than 75%) in 2 patients. Four patients with complete seizure control or excellent response in SPE had motor phenomena often evolving to secondarily generalized tonic-clonic seizures (ps-GTCS). Three patients with automatism obtained no response from CLP. In 6 patients with epilepsy undetermined whether partial or generalized (UDE), the patient with continuous spike-waves during slow wave sleep and 2 patients with generalized tonic-clonic convulsions (GTCC) showed long-term complete seizure control or long-term excellent response. These results suggest that CLP is effective for the control of SPE with convulsive (tonic or clonic) motor phenomena and ps-GTC, or UDE with GTCC.
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