Effects of sodium valproate and phenytoin on cognitive functioning in normal volunteers using event related potentials.

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We investigated the effects of sodium valproate (VPA) and phenytoin (PHT) on cognitive functioning utilizing event related potentials (ERPs), particularly N1 and P3 components. For each VPA and PHT group, twelve normal volunteers were subjected to this study. Each subject participated in two experimental sessions and was administered either real drug (VPA: 800mg/day, PHT: 200mg/day) or placebo for 1 week in a double-blind design before each session. For the ERPs measurement, we used the oddball task and to investigate the effect of taks difficulty, 3 types of stimulus conditions were employed. For the psychological test we used Wechsler Memory Scale-Revised (WMS-R) on each session. No significant effect of VPA was found on performance, correct reaction time, amplitude and latency of N1·EP3 and indexes of WMS-R. PHT of high serum level (mean serum level: 6.1μg/ml, 5 subjects) significantly reduced N1 amplitude in a specific type of stimulus condition. It may be concluded that 1) no significant effect of VPA on cognitive functioning was found in the present study, 2) PHT has negative effects on attentional functioning.
一般社団法人日本てんかん学会の論文