Role of the neutral endopeptidase in the neurogenic inflammation and bronchoconstriction
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概要
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Antidromic sensory nerve stimulation by electricity or chemical irritants can cause inflammation in many organs. Such sensory nerve stimulation can also cause bronchoconstriction. Neuropeptides, especially tachykinins like substance P, are thought to be the sensory nerve mediators. Tachykinins can be degraded by neutral endopeptidase, an enzyme that is present in the epithelium, smooth muscle, submucosal gland, in airway.<BR>The present study was performed to determine whether neurogenic inflammation or bronchoconstriction is modulated by endogenous neutral endopeptidase.<BR>1. Antidromic electrical stimulation of vagus nerve induced an increase in the pulmonary resistance in the guinea pig.<BR>2. Antidromic electrical stimulation of vagus nerve or intravenous injection of chemical irritant (capsaicin) caused neutrophil adherence to endothelium of then venules and increase in vascular permeability in the rat trachea.<BR>3. Neutral endopeptidase inhibitor phosphoramidon potentiated the magnitude of the observation of mentioned above (1 and 2). Furthermore, phosphoramidon potentiated the number of migrating neutrophils in the rat trachea.<BR>4. Aerosolized hypertonic saline increased vascular permeability in the rat trachea by producing neurogenic inflammation.<BR>These observations suggest that neutral endopeptidase modulates the inflammation or bronchoconstriction induced by endogenouslly released neuropeptides. The sensory nervous system and modulating role of the neutral endopeptidase may be important to inflammatory diseases in airway such as chronic bronchitis or bronchial asthma.
- 日本小児呼吸器疾患学会の論文