Synthesis of (S,S)-2-amino-3-phenylbutyric acid.
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概要
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(<I>S</I>,<I>S</I>)-2-Amino-3-phenylbutyric acid was synthesized starting from diethyl (<I>R</I>)-(1-phenylethyl)malonate which was obtained by desulfurization of the adduct in the stereoselective Michael reaction of (<I>R</I>)-styryl <I>p</I>-tolyl sulfoxide with diethyl malonate. This synthetic amino acid was identical with the 2-amino-3-phenylbutyric acid obtained by degradation of bottromycin and thus the absolute configuration of the naturally occurring amino acid was proved to be (<I>S</I>,<I>S</I>).
- 公益社団法人 日本化学会の論文
著者
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TSUCHIHASHI Gen-ichi
Sagami Chemical Research Center
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Ogura Katsuyuki
Sagami Chemical Research Center
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Mitamura Shuichi
Sagami Chemical Research Center
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