One-step synthesis of 3-(dialkylamino)indolizines by the palladium-catalyzed reaction of .ALPHA.-bromopyridine, propargyl alcohol, and secondary amine.

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概要

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• 3-(Dialkylamino)indolizines were synthesized in one step by the reaction of 2-bromopyridine, propargyl alcohol, and secondary amines in the presence of Pd(PPh<SUB>3</SUB>)<SUB>2</SUB>Cl<SUB>2</SUB>–CuI as a catalyst. 3-(2-Pyridyl)-2-propyn-1-ol and 3-(2-pyridyl)acrylaldehyde were suggested to be intermediates of the reaction. 3-Dialkylamino derivatives of pyrrolo[1,2-<I>a</I>]quinoline, pyrrolo[2,1-<I>a</I>]isoquinoline, and pyrrolo[1,2-<I>b</I>]pyridazine were obtained from the corresponding α-haloazaaromatics in a similar way.

• 公益社団法人 日本化学会の論文

著者

• Abe Yoshihito

  School of Pharmaceutical Sciences, Showa University

関連論文

• One-step synthesis of 3-(dialkylamino)indolizines by the palladium-catalyzed reaction of .ALPHA.-bromopyridine, propargyl alcohol, and secondary amine.

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