Studies on synthesis of 6-bromo-2,3-disubstituted 4(3H)-quinazolinones and their thiones.

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概要

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• Synthesis of some 2,3-disubstituted 6-bromo-4(3<I>H</I>)-quinazolinones is described. Treatment of some 4-quinazolinones with phosphorus pentasulfide gave the corresponding 4-quinazolinethiones. The reaction of 6-bromo-2-methyl-3,1-benzoxazin-4-one with hydroxylamine hydrochloride gave 6-bromo-3-hydroxy-2-methyl4(3<I>H</I>)-quinazolinone which on treatment with alkyl halides, acyl chlorides and sulfonyl chlorides gave the corresponding ethers, esters, and sulfonates respectively. 2-Styryl-4(3<I>H</I>)-quinazolinone derivatives are obtained by condensation of aromatic aldehydes and corresponding 3-substituted-6-bromo-2-methyl-4(3<I>H</I>)-quinazolinones. Their antibacterial affinities are of considerable efficiency.

• 公益社団法人 日本化学会の論文

著者

• Mahmoud Abdallah

  Department of Chemistry, Faculty of Science, Assiut University

関連論文

• Studies on synthesis of 6-bromo-2,3-disubstituted 4(3H)-quinazolinones and their thiones.

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