High-performance liquid chromatographic determination of organic substances by metal chelate derivatization. I. Dithiocarbamate chelates of aliphatic amines.

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概要

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• The use of the conversion of aliphatic primary and secondary amines into metal dithiocarbamate chelates was examined for high-performance liquid chromatographic determination of these amines. Characteristic chromatogram patterns based on the difference in the rate of ligand exchange were obtained for different central metal ions. When Hg(II) chelates were tested, trace determination of individual secondary amines was possible because only the peaks of binary complexes corresponding to each amine appeared on chromatograms. When Ni(II) and Pd(II) chelates were tested, peaks to ternary complexes as well as those of binary complexes appeared on chromatograms. This phenomenon was applied to the determination of optical purity of optically active amines. A description is given of applications to microdetermination of antiasthmatic ephedrine isomers, to determination of their optical purity in Chinese crude drugs, and to their preparation.

• 公益社団法人 日本化学会の論文

著者

• Endo Masaru

  Kinki District Narcotic Control Office

関連論文

• High-performance liquid chromatographic determination of organic substances by metal chelate derivatization. I. Dithiocarbamate chelates of aliphatic amines.
• Kinetic studies of fast equilibrium by means of high-performance liquid chromatography. IV. Separation of rotamers of palladium(II) dithiocarbamates.

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