New potent neuroleptic drugs of benzamide derivatives. I. Crystal and molecular structure of N-((2RS, 3RS)-1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylaminobenzamide.

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概要

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• The crystal and molecular structure of the title compound has been determined by the X-ray diffraction method. The crystal is monoclinic, space group P2<SUB>1</SUB>/c, <I>a</I>=11.694(1) Å, <I>b</I>=12.117(1) Å, <I>c</I>=14.482(1) Å, β=100.01(1)°, and <I>Z</I>=4. The structure was solved by the direct method and refined by a block-diagonal least-squares procedure to a final <I>R</I> value of 0.082. An intramolecular hydrogen bond between the amide nitrogen and the methoxyl oxygen atoms forms a new six-membered ring fused with the benzene ring. Structural features are discussed in relation to neuroleptic activity.

• 公益社団法人 日本化学会の論文

著者

• Furuya Toshio

  Product Development Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

関連論文

• New potent neuroleptic drugs of benzamide derivatives. I. Crystal and molecular structure of N-((2RS, 3RS)-1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylaminobenzamide.

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