Regioselective reaction of allylic carbanion derived from 1-phenylthio-2-octene with conjugated cyclopentenone derivative and synthesis of prostaglandin E1.

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概要

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• The reaction of the allylic carbanion derived from 1-phenylthio-2-octene with conjugated cyclopentenone derivatives in the presence of hexamethylphosphoric triamide (HMPA) regioselectively gave the 1,4 adduct at the α carbon of the allylic sulfide. The reaction was employed for the synthesis of prostaglandin E<SUB>1</SUB>.

• 公益社団法人 日本化学会の論文

著者

• NOKAMI Junzo

  Okayama University of Science

• Ono Toshio

  Okayama University of Science

• Wakabayashi Shoji

  Okayama University of Science

• Iwao Atsunori

  Okayama University of Science

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• Regioselective reaction of allylic carbanion derived from 1-phenylthio-2-octene with conjugated cyclopentenone derivative and synthesis of prostaglandin E1.

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