The synthesis of partially-protected 2'-deoxyribonucleotide dimers by the selective phosphorylation of stannylated nucleosides.

スポンサーリンク

概要

• 論文の詳細を見る

• A new method for the synthesis of the title compounds is described. The activation of the hydroxyl moieties of 5′-<I>O</I>-dimethoxytrityl and 3′,5′-<I>unprotected</I> 2′-deoxyribonucleosides, which were appropriately protected on their base residues, was done with bis(tributyltin) oxide in separate flasks. The resulting stannylated nucleosides were coupled with 2-chlorophenyl phosphorodichloridate to form the dimers with 3′→5′ internucleotide linkages in yields of more than 71%, along with the corresponding 3′→3′ isomers in yields of less than 10%. The method of Cashion <I>et al.</I> was also evaluated, in which up-to-date protecting groups were employed.

• 公益社団法人 日本化学会の論文

著者

• Kuzuhara Hiroyoshi

  RIKEN (The Institure of Physical and Chemical Research)

• Kawana Masajiro

  Riken (The Institute of Physical and Chemical Research)

• Kawana Masajiro

  RIKEN (The Institure of Physical and Chemical Research)

関連論文

• Synthesis of a Tricyclo[4.3.0.0^]-nonane Ring System from (-)-Carvone(Organic Chemistry)
• Syntheses of L-Fucopyranose and Its Homologs with Ring Heteroatoms Other than Oxygen. Stereocontrolled Conversion of a Common D-Arabinofuranoside Intermediate
• The synthesis of partially-protected 2'-deoxyribonucleotide dimers by the selective phosphorylation of stannylated nucleosides.
• Design and synthesis of macromonocyclic polyamines composed of natural methylene arrays.
• Efficient synthetic method for differentially protected naturally occurring acyclic polyamines.
• Functionalized dithia(2,5)pyridinophanes as vitamin B6 analogues. Synthesis, properties, and catalytic activity for racemization reaction.
• Synthesis and characterization of macrocyclic polyaza(2,5)pyridinophanes possessing vitamin B6 functionality.
• Chemistry of N-nitrososulfonamides. Substitution reaction by the acetyl group.

スポンサーリンク