The syntheses of the corticoid side chain. III. A new synthesis of 17.ALPHA.,21-dihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate from androsta-1,4-diene-3,17-dione.
スポンサーリンク
概要
- 論文の詳細を見る
An efficient synthesis of 17α,21-dihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate (<B>10</B>) from androsta-1,4-diene-3,17-dione (<B>1</B>), a biodegradation product of cholesterol, is described, which involves the ethynylation of the 17-ketone, the epimerization of the 17α-ethynyl group and conversion of the ethynyl group to the 20-keto pregnane. Overall yield is relatively high (about 54%) and <B>10</B> will be a potential intermediate for prednisolone.
- 公益社団法人 日本化学会の論文
著者
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Haruyama Toshio
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries Limited
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Nitta Issei
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries Limited
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Fujimori Shinichiro
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries Limited
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Inoue Shinya
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries Limited
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Ueno Hiroaki
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries Limited
関連論文
- The syntheses of the corticoid side chain. III. A new synthesis of 17.ALPHA.,21-dihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate from androsta-1,4-diene-3,17-dione.
- The syntheses of the corticoid side-chain. II. A new synthesis of 17.ALPHA.,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate from 21-hydroxy-20-methylpregna-1,4-dien-3-one.
- The syntheses of the corticoid side chain. I. An improved method for the preparation of 17.ALPHA.-hydroxyprogesterone from androst-4-ene-3,17-dione.