A convenient synthesis of cholesta-1,5,7-trien-3.BETA.-ol.

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概要

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• Cholesta-4,6-dien-3β-ol (<B>4</B>) was obtained selectively by the dehydrobromination of 7-bromocholesterol with a base in the presence of a catalytic amount of tetrabutylammonium bromide. The oxidation of <B>4</B> with 2,3-dichloro-5,6-dicyano-p-benzoquinone gave cholesta-1,4,6-trien-3-one (<B>7</B>). Treatment of <B>7</B> with isopropenyl acetate under acidic conditions afforded 3-acetoxy-1,3,5,7-cholestatetraene, which was reduced with calcium borohydride to yield cholesta-1,5,7-trien-3β-ol (<B>2</B>).

• 公益社団法人 日本化学会の論文

著者

• Tachibana Yoji

  Central Research Laboratory, Nisshin Flour Milling, Co., Ltd.

関連論文

• A convenient synthesis of cholesta-1,5,7-trien-3.BETA.-ol.

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