Acridine derivatives. I Molecular structure of the novel acridinyl-substituted uracil, 5-(9-acridinyl)-6-amino-1,3-dimethyluracil.
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概要
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The reaction of enamine between 9-chloroacridines and 6-aminouracil derivatives give novel acridine substituted uracils, the structures of which have been determined by means of an X-ray analysis of 5-(acridin-9-yl)-6-amino-1,3-dimethyluracil hydrochloride dihydrate, C<SUB>19</SUB>H<SUB>16</SUB>N<SUB>4</SUB>O<SUB>2</SUB>·HCl·2H<SUB>2</SUB>O. The crystal is triclinic with a space group <I>P</I>\bar1; also, <I>a</I>=8.763(3) <I>b</I>=16.130(9), <I>c</I>=7.620(2) Å, α=117.51(4), β=83.81(3), γ=94.21(4)°, <I>Z</I>=2, <I>V</I>=949.3 Å<SUP>3</SUP>, <I>D</I><SUB>c</SUB>=1.16 g cm<SUP>−3</SUP>, and μ=5.30 cm<SUP>−1</SUP> for Cu<I>K</I>α. The structure was solved by a direct method and refined by a block-diagonal least-squares procedure: <I>R</I>=0.074 for 2810 reflections with |<I>F</I><SUB>o</SUB>|>3σ(|<I>F</I><SUB>o</SUB>|). The crystal is composed of the title compound, chloride anion, and two molecules of water held together by hydrogen bonds (described in Table 4).
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