Radical cyclization in the control of regio- and stereochemistry.

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概要

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• This article presents a review of the control of regio- and stereochemistry which is now possible by the use of the recently introduced haloacetal and the related halosilyl ether cyclizations, starting from a cyclohexenol or a cyclopentenol. The hydroxyl group is the control element which permits the addition of two carbon chains to the double bond of the allylic alcohol system, with complete regiospecificity and stereospecificity at the near end of the double bond, and with complete regiospecificity and high stereoselectivity at the far end of the bond. Examples of the use of the new methodology from the field of alkaloid, steroid and prostaglandin synthesis are given.

• 公益社団法人 日本化学会の論文

著者

• Stork Gilbert

  Department of Chemistry, Columbia University

関連論文

• Radical cyclization in the control of regio- and stereochemistry.

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