Acyclic C-nucleoside analogs of the type of 5-C-polyhydroxyalkyl-1,3,4-thiadiazoles.
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概要
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The synthesis of some acyclic <I>C</I>-nucleoside analogs possessing thiadiazole rings was achieved by the heterocyclization of the 4-arylthiosemicarbazones of D-galactose, D-glucose, D-mannose, D-arabinose, and lactose, Acetylation of the thiadiazoles afforded the corresponding 2-(<I>N</I>-acetylarylamino)-5-polyacetoxyalkyl-1,3,4-thiadiazoles and periodate oxidation gave the corresponding 5-(arylamino)-1,3,4-thiadiazole-2-carbaldehyde.
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著者
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Mousaad Ahmed
Chemistry Department, Faculty of Science, Alexandria University
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El Ashry
Chemistry Department, Faculty of Science, Alexandria University
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Nassr Mahmoud
Chemistry Department, Faculty of Science, Alexandria University
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El Kilany
Chemistry Department, Faculty of Science, Alexandria University