A convenient reductive removal of benzylic hydroxyl and trimethylsilyloxyl groups with Me3SiCl-NaI-MeCN reagent.

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概要

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• Secondary and tertiary hydroxyl groups at benzylic positions were reductively removed by treatment with 6 equivalents of Me<SUB>3</SUB>SiCl–NaI–MeCN reagent in hexane at room temperature. A benzylic trimethylsilyloxyl group was also eliminated by the addition of 2 equivalents of water to the reaction system. The reduction was applied to the syntheses of precursors of such anti-inflammatory agents as ibuprofen, butibufen, naproxen, and related compounds, as well as (±)-<I>ar</I>-turmerone, an odorous sesquiterpene.

• 公益社団法人 日本化学会の論文

著者

• Miyata Kazuyoshi

  Department of Applied Chemistry, Faculty of Engineering, Okayama University

関連論文

• A convenient reductive removal of benzylic hydroxyl and trimethylsilyloxyl groups with Me3SiCl-NaI-MeCN reagent.

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