Preparation of optically active 1-aminoalkylphosphonic acids from chiral carbamates and chiral ureas.

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概要

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• Optically active 1-aminoalkylphosphonic acids were successfully synthesized from chiral carbamate and urea derivatives which were prepared from such chiral substrates as (−)-menthol, (+)-camphor, and (<I>R</I>)-(+)-and (<I>S</I>)-(−)-(1-phenylethyl)ureas by the actions of aldehydes and triaryl phosphites. 1-Aminoalkylphosphonic acid derivatives, thus prepared, have an (<I>R</I>)-(+)- or (<I>S</I>)-(−)-configuration, depending on the chiral source via a retention of the configuration; i.e., (+)-products were prepared from chiral (+)-carbamate and (+)-urea derivatives, and (−)-products from chiral (−)-carbamate and (−)-urea derivatives.

• 公益社団法人 日本化学会の論文

著者

• Oshikawa Tatsuo

  Department of Applied Chemistry, Faculty of Engineering, Shizuoka University

関連論文

• Preparation of optically active 1-aminoalkylphosphonic acids from chiral carbamates and chiral ureas.

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