Preparation of 3,6-disubstituted pyridazines from 3-thiapentane-1,5-diones via 2,7-dihydro-1,4,5-thiadiazepines.
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概要
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A series of 3-thiapentane-1,5-diones condense with hydrazine in the presence of a catalytic amount of <I>p</I>-toluenesulfonic acid in refluxing ethanol to give 2,7-dihydro-1,4,5-thiadiazepines in excellent yields. Thermal decomposition of the latter compounds in refluxing diethylene glycol affords the corresponding pyridazines in high yields with evolution of hydrogen sulfide. The above procedure is generally applicable to the preparation of a wide variety of 3,6-disubstituted pyridazines which are of structural interest and otherwise difficult to prepare.
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著者
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Ishii Akihiko
Department Of Chemistry Faculty Of Science Saitama University
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Nakayama Juzo
Department Of Chemistry Faculty Of Science Saitama University
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Hoshino Masamatsu
Department of Chemistry, Faculty of Science and Engineering, Saitama University
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Konishi Toru
Department of Chemistry, Faculty of Science, Saitama University
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