Copper(I) salt catalyzed reaction of 1,1,1-trichloro-2,2,2-trifuloroethane with trimethylsilyl enol ethers. A convenient synthesis of .BETA.-chloro-.BETA.-(trifluoromethyl) .ALPHA.,.BETA.-unsaturated carbonyl compounds.

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概要

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• β-Chloro-β-(trifluoromethyl) α,β-unsaturated carbonyl compounds were obtained by the reaction of trimethylsilyl enol ethers with CF<SUB>3</SUB>CCl<SUB>3</SUB> and CuCl, followed by dehydrochlorination with triethylamine or DBN. Aromatic enol ethers gave moderate to good yields of the chloro(trifluoromethyl)methylene ketone derivatives but aliphatic enol ethers and silyl ketene acetal gave only lower yields.

著者

• Okano Takashi

  Institute of Applied Organic Chemistry, Faculty of Engineering, Nagoya University

関連論文

• Copper(I) salt catalyzed reaction of 1,1,1-trichloro-2,2,2-trifuloroethane with trimethylsilyl enol ethers. A convenient synthesis of .BETA.-chloro-.BETA.-(trifluoromethyl) .ALPHA.,.BETA.-unsaturated carbonyl compounds.

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