Synthesis of .ALPHA.-amino acids containing a cyclopropane ring via cobalt-catalyzed carbonylation-amidocarbonylation of cyclopropanemethanols.

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概要

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• <I>N</I>-Acetyl-3-cyclopropylalanine and 2-acetamido-3-cyclopropylbutyric acid were prepared under cobalt-catalyzed amidocarbonylation conditions from cyclopropanemethanol and α-methylcyclopropanemethanol, respectively. The reaction has been estimated to comprise the <I>in situ</I> formation of aldehyde from alcohol by cobalt-catalyzed hydrocarbonylation followed by subsequent amidocarbonylation.

• 公益社団法人 日本化学会の論文

著者

• Izawa Kunisuke

  Central Research Laboratories Ajinomoto Co. Inc.

• Amino Yusuke

  Central Research Laboratories, Ajinomoto Co.

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• Synthesis of .ALPHA.-amino acids containing a cyclopropane ring via cobalt-catalyzed carbonylation-amidocarbonylation of cyclopropanemethanols.

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