Hydroformylation-Amidocarbonylation of Methylvinylphosphinate. Application to Synthesis of Glufosinate.

スポンサーリンク

概要

• 論文の詳細を見る

• Glufosinate, 2-amino-4-[(hydroxy)methylphosphinyl]butanoic acid, (<B>2a</B>) was synthesized from 2-chloroethyl methylvinylphosphinate (<B>1a</B>) via successive hydroformylation–amidocarbonylation. Hydroformylation of <B>1a</B> catalyzed by Co<SUB>2</SUB>(CO)<SUB>8</SUB> in methanol gave 2-chloroethyl (3,3-dimethoxypropyl)methylphosphinate (<B>5</B>). Crude <B>5</B> was subjected to cobaltcatalyzed amidocarbonylation to afford <I>N</I>-acylglufosinic acid methyl ester (<B>2b</B>). Hydrolysis of <B>2b</B> under acidic conditions gave <B>2a</B> quantitatively.

• 公益社団法人 日本化学会の論文

著者

• Huang Xin-Yan

  National Chemical Laboratory for Industry

関連論文

• Hydroformylation-Amidocarbonylation of Methylvinylphosphinate. Application to Synthesis of Glufosinate.

スポンサーリンク