Synthesis of Corticotropin Peptides. IX. Synthesis of [1-Glycine]-ACTH(1–18)-Octadecapeptide Amide

スポンサーリンク

概要

• 論文の詳細を見る

• The synthesis is decribed of an octadecapeptide, glycyl-tyrosyl-seryl-methionyl-glutamyl-histidyl-phenyl-alanyl-arginyl-tryptophyl-glycyl-lysyl-prolyl-valyl-glycyl-lysyl-lysyl-arginyl-arginine amide, corresponding to the first eighteen amino acid residues of corticotropin except for the amino end which has been replaced by a glycine for the serine in the native hormone. The protected end product was obtained by two different coupling procedures, the active ester and the catalyzed carbodiimide, from the amino-terminal decapeptide and the octapeptide of carboxyl end. The over-all yields of the peptide, for the final coupling, deblocking and purification steps, in the active ester and the carbodiimide procedures were approximately forty and thirty per cent, respectively. The synthetic octadecapeptide amide has been shown to possess a high adrenal corticotropic activity, which is comparable to that of the corresponding 1-serine octadecapeptide amide, and a lipolytic activity which is significantly lower than that of the 1-serine analog.

• 公益社団法人 日本化学会の論文

著者

• Inouye Ken

  Biochemistry Division, Shionogi Research Laboratory, Shionogi & Co., Ltd.

• Otsuka Hideo

  Biochemistry Division, Shionogi Research Laboratory, Shionogi & Co., Ltd.

• Shin Masaru

  Biochemistry Division, Shionogi Research Laboratory, Shionogi & Co., Ltd.

• Kinomura Yasuhiko

  Biochemistry Division, Shionogi Research Laboratory, Shionogi & Co., Ltd.

関連論文

• Synthesis of a Heptacosapeptide Corresponding to the Human Corticotropin 1-27 Sequence
• Synthesis of Corticotropin Peptides. XII. The Effect of Amino-terminal Substitution in the Corticotropin 1-18 Peptide
• A Synthesis of Thyrotropin-Releasing Factor
• Synthesis of Corticotropin Peptides. IX. Synthesis of [1-Glycine]-ACTH(1–18)-Octadecapeptide Amide

スポンサーリンク