Amino Acids and Peptides. I. Syntheses of <I>p</I>-Methoxybenzyl <I>p</I>-Nitrophenyl Carbonate, <I>p</I>-Methoxybenzyl Carbazate, and <I>p</I>-Methoxybenzyloxycarbonyl Amino Acids with <I>p</I>-Methoxybenzyl Chloroformate

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概要

• 論文の詳細を見る

• A new method for the syntheses of <I>p</I>-methoxybenzyl <I>p</I>-nitrophenyl carbonate, <I>p</I>-methoxybenzyl carbazate, and <I>p</I>-methoxybenzyloxycarbonyl amino acids has been devised. These compounds were obtained in satisfactory yield from sodium <I>p</I>-nitrophenolate, 85% hydrazine hydrate, and several amino acids with <I>p</I>-methoxybenzyl chloroformate prepared from anisyl alcohol and phosgene in the presence of dimethylaniline in dry ether at −5–−10°C. This direct <I>p</I>-methoxybenzyloxycarbonylation of amino acid with the chloroformate is more convenient than the usual Weygand method.

• 公益社団法人 日本化学会の論文

著者

• Sofuku Shosuke

  Department of Chemistry, Faculty of Science, Rikkyo (St. Paul's) University

関連論文

• Amino Acids and Peptides. I. Syntheses of p-Methoxybenzyl p-Nitrophenyl Carbonate, p-Methoxybenzyl Carbazate, and p-Methoxybenzyloxycarbonyl Amino Acids with p-Methoxybenzyl Chloroformate

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