Total Syntheses of Holomycin, Thiolutin, and Aureothricin

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概要

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• The reactions of 4-benzylthio-5-benzylthiomethyl-3-hydroxy-2-oxo-2,5-dihydrofuran with ammonia and primary amines gave 3-amino-4-benzylthio-5-benzylthiomethyl-3-pyrrolin-2-one derivatives. 3-Acylamino-4-benzylthio-5-benzylthiomethylene-3-pyrrolin-2-one derivatives, including the intermediate of the synthesis of holomycin by Büchi, were prepared by the treatment of the 3-acylaminolactams derived from the 3-aminolactams with chloranil or DDQ. Thiolutin and aureothricin were also synthesized from 3-acetamido- and 3-propionamido-4-benzylthio-5-benzylthiomethylene-1-methyl-3-pyrrolin-2-one respectively.

• 公益社団法人 日本化学会の論文

著者

• YONEDA Naoto

  Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.

• Hagio Katsuaki

  Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.

関連論文

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• A Facile Synthesis of 6-Chloro-D-tryptophan
• Synthesis and Herbicidal Activities of α-Isocyanocycloalkylideneacetamides1)
• Total Syntheses of Holomycin, Thiolutin, and Aureothricin

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