New method for synthesis of various types of substituted 2(5H)-furanones.

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概要

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• A combination of the reaction of dianions of (phenylthio) acetic acid and its homologs with epoxides, the conjugate addition reaction of 3-phenylthio-2-(5<I>H</I>)-furanones with carbanion species, and the α-alkylation reaction of α-phenylthio-γ-butyrolactones is shown to provide a general method for the synthesis of a variety of substituted α-phenylthio-γ-butyrolactones. Oxidation of these α-phenylthiolactones to the corresponding sulfoxides, followed by pyrolysis furnishes all the types of substituted (3-, 4-, and 5-mono-; 3,4-, 3,5- 4,5-, and 5,5-di-; 3,4,5-tri-) 2(5<I>H</I>)-furanones in good overall yields.

• 公益社団法人 日本化学会の論文

著者

• Uda Hisashi

  Chemical Research Institute Of Non-aqueous Solutions Tohoku University

• Kosugi Hiroshi

  Chemical Research Institute of Non-aqueous Solutions, Tohoku University

• Iwai Kiyoshi

  Chemical Research Institute of Non-Aqueous Solutions, Tohoku University

• Kawai Mikio

  Chemical Research Institute of Non-Aqueous Solutions, Tohoku University

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