Dehydration of Bile Acids and their Derivatives. X. A Study of the Physical Properties of Various 3α-Hydroxycholenates and their Derivatives, with Special Reference to their Optical Rotatory Dispersions
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Not only ultraviolet and infrared absorption spectra but also optical rotatory dispersions of various unsaturated bile acids were studied, and most of the data were found to be in good agreement with those hitherto obtained concerning the other steroids. The determination of the rotatory dispersion gave the following results:<BR>1) The background rotation of the saturated bile acid is not affected by the introduction of a double bond in ring B, C or D.<BR>2) The introduction of a double bond in ring C or D does not remarkably affect the RD curve of the saturated 3-keto bile acids, while the negative drift of the RD curve given by 3-keto-<I>Δ</I><SUP>6</SUP>-cholenic acid is so very striking that this phenomenon could be utilized for the diagnosis of <I>Δ</I><SUP>6</SUP>-3-keto bile acids (5β).<BR>3) The positive Cotton-effect RD curve given by a saturated 12-keto bile acid is strongly inverted by the introduction of the <I>Δ</I><SUP>8(14)</SUP>-bond, but not by that of the <I>Δ</I><SUP>8</SUP>-bond.
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