THE EFFECTS OF DRUGS ON THE MEMBRANE ACTIVITIES OF THE TOAD SARTORIUS MUSCLE

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概要

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• 1. The effects on the membrane activities of the toad sartorius muscle of veratrine, aconitine, veriloid, calcium-free solution, guanidine, TEA, quinine, caffeine, excess of K<SUP>+</SUP> ion, procaine and CuO<SUP>+</SUP> ion were investigated with an intracellular recording electrode.<BR>2. Veratrine produced repetitive muscle spikes when single shock stimulation was applied either to the nerve or muscle.<BR>Veriloid, aconitine and calcium-free solution have been observed to produce such repetitive responses.<BR>Guanidine produced repetitive muscle spikes only if a motor nerve volley was applied.<BR>3. Veratrine, aconitine, veriloid, guanidine, quinine, TEA and procaine did not alter the resting potential. Excess of K<SUP>+</SUP> ion, caffeine and CuO<SUP>+</SUP> ion produced a marked fall in the resting potential.<BR>4. Veratrine, aconitine, TEA and guanidine increased the size of the e.p.p. in the low-sodium muscle, whereas caffeine, quinine, veriloid and CuO<SUP>+</SUP> ion decreased it. Procaine was ineffective or only slightly diminished the size.

• 公益社団法人 日本薬理学会の論文

著者

• YANAI AKIRA

  Department of Pharmacology, Faculty of Medicine, Kyoto University

• MATSUMURA MOTOHATSU

  Department of Pharmacology, Faculty of Medicine, Kyoto University

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