THE MODE OF ACTION OF ω-AMINOACYLCHOLINES ON THE NEURO-MUSCULAR JUNCTION

概要

論文の詳細を見る
The effects of 5-aminopentanoyl- (I), 6-aminohexanoyl- (II) and 7-aminoheptanoyl- (III) cholines and 6-aminohexanoy11-β-methylcholine chlorides on the neuromuscular junction were studied in dogs' and cats' tibial and gastrocnemius muscles. 1. Compounds (II) and (III) have the same potency of neuromuscular blocking (one tenth potency of succinylcholine), compound (I) and, β-methyl analogue of (II) have one-fifth and one-two hundredth potency of compound (II). 2. The induction and the restoration were very rapid. No so-called dual block phenomenon was observed. 3. The initial facilitation of twitch, the fasciculation in the time of induction, the antagonism to d-Tc and the potentiation of N-M blocking by edrophonium, TMA, TPA and TBA were observed. 4. The pattern of tetanic contraction, and the antagonism between ω-aminoacyl-cholines and TEA were similar to those in the case of d-Tc. 5. β-Methyl analogue of compound (II) showed both antagonism and synergism to compound (II) in the different animals. The ratio of occurrence is fifty to fifty. This analogue showed also temporarily the stimulation of respiration and the increase of system is blood pressure in the intravenous administration. ω-Aminoacylcholines have the same pressor effect in almost same potency. 6. The authors discussed the mechanism of these compounds in reference to the neuro-muscular blocking by d-Tc.
公益社団法人日本薬理学会の論文