ANTISYMPATHOMIMETIC EFFECTS OF Kö 1313 AND Kö 1366 IN GUINEA-PIG ATRIA

概要

論文の詳細を見る
The antagonistic effects of two new β-receptors blocking agents, Kö 1313 and Kö 1366 against the chronotropic and inotropic responses to noradrenaline and tyramine were studied on the isolated right and left atria of guinea-pigs. From the K<SUB>B</SUB> values estimated by means of three different methods, it was found that the potencies of Kö 1366 were 5 to 10 times and 5 to 7 times those of Kö 1313 in the antagonism against chronotropic and inotropic effects of noradrenaline respectively. From the depression of maximum chronotropic and inotropic effects of tyramine in the presence of these agents, Kö 1366 was demonstrated to be approx. three times more potent than Kö 1313 in the antagonism against both effects of tyramine.
公益社団法人日本薬理学会の論文