ラットの胎仔ならびに哺育仔の発育におよぼす合成LH-RHの影響

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Synthetic luteinizing hormone-releasing hormone (LH-RH) was administered to pregnant Wistar rats for the examination of delivery and pre-postnatal development of their offspring. The compound was given to the rats intravenously, in doses of 6, 15, 30 600 and 6000 μg/kg/day, for 6 days from day 9 to day 14 of gestation. The results are summarized as follows : (1) No significant toxicity was observed in the rat mothers during the medication period. Body weight gain of the mothers were comparable for all groups. (2) Autopsy of the full-term mothers revealed an increase in the number of corpola lutea at doses of 60,600 and 6000 μg/kg. (3) Intrauterine mortalities and mean body weights of fetuses are considered to be unaffected by the treatment at any dosage. (4) Among live fetuses there were no malformations attributable to the LH-RH treatment, nor any tendency toward masculinization. (5) Some of mothers receiving 15 and 30 μg/kg of LH-RH had the onset of labor delayed for a few days. At the doses of 60,600 and 6000 μg/kg, the delays in paturition were more remarkable. Almost half of the mothers in these groups left fetuses in utero, and resulted in death by bacterial infection. (6) As for the normally delivered offsprings, both the postnatal development and sexual maturation were quite satisfactory. (7) The vialbility of the fetuses delivered from the LH-RH treated mothers by cesarotomy was confirmed by foster nursing. From the facts obtained in the present study, we may conclude as follows : Synthetic LH-RH has no adverse effects on the pre- and postnatal development of rat fetuses, but a delaying effect on parturition is evident with daily doses of more than 15 μg/kg.
日本内分泌学会の論文

ラットの胎仔ならびに哺育仔の発育におよぼす合成LH-RHの影響

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