バセドウ病及び橋本病におけるT細胞, B細胞とその意義:(1) 末梢血における数的変動

概要

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T and B cells were counted in the peripheral blood of patients with Graves' disease and Hashimoto's thyroiditis in an attempt to investigate an increased compartment of lymphocytes which is generally observed in the peripheral blood of the two diseases.<BR>In the Graves patients, T cells with the ability to bind fresh sheep red cells at low temperatures (0-4°C) were found generally increased in untreated cases. However, they were found to be greatly reduced in permanent-hypothyroid patients caused by an overdose of radioiodine ; the restoration of T cell counts in these patients was successful 2 or 3 months after supplementary administration of thyroid hormone. An abrupt reduction in T cell counts in the patients treated with MMI or PTU suggests that these drugs may be immuno-repressants. Thus, peripheral T cell counts are strongly related to thyroid states or serum levels of thyroid hormone in Graves' disease. On the other hand, although T cell counts were also found to be increased in the peripheral blood of Hashimoto patients, its mechanism is supposed to be mainly based on immunological reactions. It is possible that the mechanism of the T cell increase is different between the two diseases.<BR>Ig bearing lymphocytes (B cells) in the peripheral blood were determined after a standard immunofluorescence method. They were found significantly increased in Hashimoto patients but not in Graves patients.
一般社団法人日本内分泌学会の論文