感作抗原ならびにPHA, PWMによるヒトサイロクロブリン感作ラットリンパ球の反応

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Since the presence of auto-immunity in Hashimoto's thyroiditis and Grave's disease has deen reported, several workers have demonstrated their findings suggesting a possible relationship between the pathogenesis of thyroid auto-immune reactions and circulating lymphocytes which might complete these auto-immune processes. However, despite the high incidence of auto-immunity in these diseases, there are few successful reports and few investigations using lymphocytes from experimental animals. To investigate the lymphoid immune system in experimental thyroiditis, the in vitro responses to phytohemagglutinin (PHA), pokeweed mitogen (PWM) and human thyroglobulin were measured for spleen cells from normal rats and rats immunized by human thyroglobulin in this paper. Our results were as follow : 1) For immunized lymphocytes, the response of PWM which stimulates both B-and T-cell was obviously higher than PHA which stimulates only T-cell. 2) Human thyroglobulin stimulated immunized rat lymphocytes but not the normal ones. 3) Rat lymphocytes stimulated by human thyroglobulin synthesize thyroglobulin anti-bodies but those stimulated by PHA or PWM do not.
一般社団法人日本内分泌学会の論文