日本婦人乳癌組織のestrogen receptorについて

概要

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There is a great difference in breast cancer incidence between Japanese and American women. Jensen et al have determined estrogen receptors on American female breast cancer cytosols mainly by the method of sucrose density gradients. In the present paper, estrogen receptors in forty-eight Japanese female breast cancer cytosols from forty-four patients were determined by the sucrose density gradients, and the results were compared to those by Jensen et al. The influence of age, endocrine circumstances, pathological and hereditary conditions on the occurrence of estrogen receptors was also described.<BR>1. In the present study, the occurrence of estrogen receptors was positive in 27%. Jensen reported a 46% occurrence. The incidence of breast cancer is lower in Japan than in the United States. This lower incidence can not be explained by the lower percentage of estrogen receptor positive cases.<BR>2. More estrogen receptors were present in postmenopausal women than in premenopausal women, in papillotubular carcinomas than in scirrhus carcinomas, and in artificial feeding than in breast or mixed feeding.<BR>Endocrine therapy may be choosen for Clnical use, according to estrogen receptors determination. Endocrine therapy is effective in positive cases.
日本内分泌学会の論文