Glucoseの立体異性体, Galactoseの負荷による血中Insulinの動態に関する臨床的研究
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The galactose tolerance tests were performed using the recently developed galactose-dehydrogenase technique in normal, hepatic and diabetic cases. The results obtained were compared with glucose tolerance tests, and in particular the changes of carbohydrate metabolites were investigated.<BR>In all cases, no significant changes of plasma IRI during galactose loading tests were found with both oral and intravenous administration. Furthermore, a correlation between ΔIRI and Δgalactose was not statistically recognized.<BR>The correlation between ΔIRI and Δglucose was significant in normal subjects in oral glucose tolerance tests, but not significant in galactose tolerance tests. However, no correlation was observed in the groups of diseases in both oral glucose and galactose tolerance tests.<BR>In the relationship between ΔIRI and ΔNEFA, slightly positive correlation was found in normal subjects during oral glucose loading, whereas a tendency of negative correlation was found in them during oral galactose loading. This tendency was particularly remarkable in patients with liver diseases whose blood galactose levels were retarded.<BR>The decrease in blood NEFA levels during oral galactose loading were compared with the glucose tolerance tests. The decrease of NEFA following oral galactose loading reached a maximum level after 1 hour. On the other hand, the decrease following glucose loading was still maintained after 2 hours, and was more remarkably compared to galactose loading. It was thought that the initial decrease in blood NEFA levels between 30 and 60 minutes after loading was induced by the direct action of galactose or glucose, and the continuous decrease up to 2 hours after glucose loading was caused by insulin release.
- 日本内分泌学会の論文
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